MOTS-C Frequently Asked Questions

MOTS-C is a 16-amino acid peptide encoded within the 12S rRNA gene of mitochondrial DNA. It is a mitochondrial-derived peptide (MDP) that was identified by Professor Pinchas Cohen's laboratory at the University of Southern California. MOTS-C is often referred to as an 'exercise mimetic' due to its metabolic effects. Peptides Pharma MOTS-C is formulated at >99% purity in a lyophilized vial.

Research indicates MOTS-C activates the AMPK pathway, a key cellular energy sensor, and can translocate to the cell nucleus to regulate gene expression related to metabolic stress responses. It influences glucose metabolism by promoting GLUT4 translocation and enhancing cellular glucose uptake. Studies suggest it may also modulate the folate-methionine cycle, linking mitochondrial signalling to nuclear gene regulation.

MOTS-C is studied in research related to metabolic regulation, insulin sensitivity, obesity models, exercise physiology, cellular aging, mitochondrial function, and physical performance. Its exercise-mimetic properties make it particularly relevant to metabolic health and healthspan research.

Peptides Pharma MOTS-C is manufactured to >99% purity in GMP-certified, ISO 7 cleanroom facilities. Each batch is independently verified by HPLC and mass spectrometry testing. Certificates of Analysis are available for all production batches.

Lyophilized MOTS-C should be stored at -20°C for long-term storage or at 2-8°C for short-term use. Protect from direct light and moisture. After reconstitution, store at 2-8°C and use within 28 days for best results.

Reconstitute MOTS-C by slowly adding bacteriostatic water down the inside wall of the vial. Allow the lyophilized powder to dissolve without shaking — gently swirl until fully dissolved. The reconstitution volume determines the concentration for your research dosing calculations.

Reconstituted MOTS-C stored at 2-8°C with bacteriostatic water is generally stable for up to 28 days. Use aseptic technique when withdrawing doses to maintain sterility and peptide integrity throughout the research period.

Yes. Peptides Pharma MOTS-C is supplied exclusively for laboratory and research purposes. It is not approved as a medicine and is not intended for human therapeutic use. Researchers should comply with all applicable institutional and regulatory requirements.

Both MOTS-C and Humanin are mitochondrial-derived peptides (MDPs) encoded within mitochondrial DNA, but they act through different mechanisms. Humanin is primarily cytoprotective and anti-apoptotic, while MOTS-C is metabolic-regulatory and exercise-mimetic. Together, they represent a class of signalling molecules that link mitochondrial function to systemic health.

MOTS-C is sometimes studied alongside other mitochondrial-derived peptides like Humanin, as well as metabolic compounds such as AOD-9604 and NAD+. These combinations allow researchers to investigate complementary metabolic and cytoprotective pathways. Protocol design should be based on published research literature.