Humanin Frequently Asked Questions

Humanin is a 24-amino acid peptide encoded by mitochondrial DNA, making it one of the few known mitochondrial-derived peptides (MDPs). It was originally identified in a screen for factors that protect neurons from amyloid-beta toxicity associated with Alzheimer's disease. Peptides Pharma Humanin is formulated at >99% purity in a lyophilized vial.

Research indicates Humanin exerts its cytoprotective effects through multiple pathways including binding to the IGFBP-3 receptor and the formyl peptide receptor-like 1 (FPRL1). It is thought to inhibit apoptosis (programmed cell death) by interacting with Bax, a pro-apoptotic protein, and by activating the STAT3 signalling pathway. These mechanisms contribute to cellular survival under stress conditions.

Humanin is studied in research related to neuroprotection, Alzheimer's disease models, mitochondrial dysfunction, cellular stress responses, cardiovascular protection, metabolic regulation, and age-related decline. Its role as an endogenous cytoprotective factor makes it a key molecule in aging and longevity research.

Peptides Pharma Humanin is manufactured to >99% purity in GMP-certified, ISO 7 cleanroom facilities. Each batch undergoes independent HPLC and mass spectrometry verification. Certificates of Analysis confirming identity, purity, and sterility are available for all batches.

Lyophilized Humanin should be stored at -20°C for long-term storage or 2-8°C for short-term use. Protect from light and moisture. After reconstitution, store at 2-8°C and use within 28 days to maintain peptide integrity.

Reconstitute Humanin by adding bacteriostatic water gently down the inner wall of the vial. Allow the lyophilized powder to dissolve without vigorous agitation — swirl gently if needed. The reconstitution volume determines the final concentration for your research protocol.

Reconstituted Humanin stored with bacteriostatic water at 2-8°C is generally stable for up to 28 days. Maintain aseptic technique when drawing from the vial to preserve sterility and peptide quality throughout the usage period.

Yes. Peptides Pharma Humanin is supplied exclusively for laboratory and research applications. It is not approved as a therapeutic agent and is not intended for human clinical use. All research should comply with applicable institutional and regulatory requirements.

Studies indicate that circulating Humanin levels decline with age in both humans and animal models. This decline correlates with increased susceptibility to age-related diseases including neurodegenerative conditions and metabolic dysfunction. Humanin is therefore studied as both a biomarker of mitochondrial health and a potential research tool in geroscience.

Humanin is sometimes studied alongside other mitochondrial-derived peptides such as MOTS-C, as well as anti-aging compounds like Epithalon and NAD+. These combinations allow researchers to investigate complementary cytoprotective mechanisms. Protocol design should follow published literature and institutional guidelines.